Adrenal zonation: clues from 11β-hydroxylase and aldosterone synthase
作者： William E. Rainey
DOI: 10.1016/S0303-7207(99)00051-9
关键词: Aldosterone 、 Adrenal gland 、 Adrenal cortex 、 Aldosterone synthase 、 Angiotensin II 、 Chemistry 、 Mineralocorticoid 、 Endocrinology 、 Internal medicine 、 Steroid 11-beta-hydroxylase 、 Glucocorticoid
摘要: Abstract Aldosterone and cortisol are the major mineralocorticoid glucocorticoid produced by human adrenal. Circulating levels of angiotensin II potassium control adrenal production aldosterone, while is controlled mainly adrenocorticotropin. The capacity cortex to differentially produce aldosterone relies a large degree on expression synthase ( CYP11B2 ) 11β-hydroxylase CYP11B1 ). catalyzes final steps in biosynthesis expressed solely glomerulosa cortex, fasciculata/reticularis. zonal these two isozymes appears result from transcriptional regulation genes. Herein, recent progress defining cellular mechanisms that regulate transcription thus gland discussed.
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