Multiple roles for sphingolipids in steroid hormone biosynthesis.
作者： Natasha C. Lucki , Marion B. Sewer
DOI: 10.1007/978-1-4020-8831-5_15
关键词:
摘要: Steroid hormones are essential regulators of a vast number physiological processes. The biosynthesis these chemical messengers occurs in specialized steroidogenic tissues via multi-step process that is catalyzed by members the cytochrome P450 superfamily monooxygenases and hydroxysteroid dehydrogenases. Though numerous signaling mediators, including cytokines growth factors control steroidogenesis, trophic peptide primary steroid hormone production. These activate cAMP/cAMP-dependent kinase (PKA) pathway, however, studies have shown crosstalk between multiple signal transduction pathways molecules modulates optimal capacity. Sphingolipids such as ceramide, sphingosine, sphingosine-1-phosphate, sphingomyelin, gangliosides been to biosynthetic pathway at levels, regulating gene expression activity well acting second cascades. In this review, we provide an overview recent investigated role sphingolipids adrenal, gonadal, neural steroidogenesis.
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