Risk factors for brain metastases in surgically staged IIIA non-small cell lung cancer patients treated with surgery, radiotherapy and chemotherapy.
作者： Marina Petrovic , Nevenka Ilic , Olivera Loncarevic , Ivan Cekerevac , Zorica Lazic
DOI: 10.2298/VSP1108643P
关键词: Carcinoma 、 Oncology 、 Neoadjuvant therapy 、 Internal medicine 、 Lung cancer 、 Radiation therapy 、 Stage (cooking) 、 Chemotherapy 、 Medicine 、 Lung 、 Lower risk 、 Surgery
摘要: Introduction/Aim. Lung cancer is a leading cause of mortality among patients with carcinomas. The aim this study was to point out risk factors for brain metastases (BM) appearance in patients IIIA (N2) stage nonsmall cell lung (NSCLC) treated three-modal therapy. Methods. We analyzed data obtained from 107 NSCLC surgically neoadjuvant frequency brain examined regarding age, sex, histological type and the size of tumor, nodal status, sequence radiotherapy chemotherapy application chemotherapy. Results. Two 3-year incidence rates BM were 35% 46%, respectively. Forty-six percent recurred as their first failure period three years. Histologically, nonsquamous carcinoma had significantly higher compared the group squamous (46% : 30%; p = 0.021). Examining treatment-related parameters, treatment taxane-platinum containing regimens associated lower metastases, than platinum-etoposide chemotherapy (31% 52%; 0.011). Preoperative radiotherapy, or without postoperative treatment, showed rate treatment only (33% 48%; 0.035). Conclusion. Brain are often site recurrence NSCLC (IIIA-N2). Autonomous non-squamous NSCLC, N1-N2 preoperative radiotherapy.
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