A Systematic Review of Risk Factors for Brain Metastases and Value of Prophylactic Cranial Irradiation in Non-Small Cell Lung Cancer
作者： Dian-Shui Sun , Li-Kuan Hu , Ying Cai , Xiao-Mei Li , Lan Ye
DOI: 10.7314/APJCP.2014.15.3.1233
关键词:
摘要: Background The incidence of brain metastases (BM) varies in patients with non-small cell lung cancer (NSCLC), calls into question the value prophylactic cranial irradiation (PCI). It is possible that clinicopathologic characteristics are associated development BM, but these have yet to be identified detail. Thus, we conducted present meta-analysis on risk factors for BM and PCI NSCLC. Methods Eligible data were extracted NSCLC analyzed by calculating pooled odds ratio (OR). Heterogeneity was detected using Q I-squared statistics, publication bias tested funnel plots Egger's test. Results Six randomized controlled trials a focus 13 eligible studies included. significantly reduced (p=0.000, OR=0.34, 95% confidence interval = 0.37-0.59). Compared non-squamous carcinoma, squamous carcinoma low OR=0.47, =0.34- 0.65). plot test suggested there no current meta-analysis. Conclusions This provides statistical evidence compared can used as predictor NSCLC, might reduce does not provide survival benefit.
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