Modulation of molecular mechanisms involved in protein synthesis machinery as a new tool for the control of cell proliferation

作者: Michele Caraglia , Alfredo Budillon , Giovanni Vitale , Giovanni Lupoli , Pierosandro Tagliaferri

DOI: 10.1046/J.1432-1327.2000.01465.X

关键词: Cell growthCell biologyNeoplastic transformationCarcinogenesisGenetic enhancementBiologyTranslation (biology)Protein biosynthesisSignal transductionDNA

摘要: … intersubunit cavity is opened upon starvation for amino-acylated… the double-stranded RNA-dependent protein kinase (dsRNA-… suppresses proliferation of human T lymphocytes in vitro …

参考文章(258)
Tony DeBlasio, Mark Rubin, Zhen Fan, Andrew Koff, Tim Soos, John Mendelsohn, Xipu Wu, Involvement of p27KIP1 in G1 arrest mediated by an anti-epidermal growth factor receptor monoclonal antibody. Oncogene. ,vol. 12, pp. 1397- 1403 ,(1996)
O. Donzé, R. Jagus, A. E. Koromilas, J. W. Hershey, N. Sonenberg, Abrogation of translation initiation factor eIF-2 phosphorylation causes malignant transformation of NIH 3T3 cells. The EMBO Journal. ,vol. 14, pp. 3828- 3834 ,(1995) , 10.1002/J.1460-2075.1995.TB00052.X
N. T. Redpath, E. J. Foulstone, C. G. Proud, Regulation of translation elongation factor‐2 by insulin via a rapamycin‐sensitive signalling pathway. The EMBO Journal. ,vol. 15, pp. 2291- 2297 ,(1996) , 10.1002/J.1460-2075.1996.TB00582.X
Barbara H. Iglewski, Jerald C. Sadoff, [69] Toxin Inhibitors of protein synthesis: production, purification, and assay of Pseudomonas aeruginosa toxin A Methods in Enzymology. ,vol. 60, pp. 780- 793 ,(1979) , 10.1016/S0076-6879(79)60071-X
A. Björnsson, S. Mottagui-Tabar, L. A. Isaksson, Structure of the C-terminal end of the nascent peptide influences translation termination. The EMBO Journal. ,vol. 15, pp. 1696- 1704 ,(1996) , 10.1002/J.1460-2075.1996.TB00515.X
E W Gelfand, K Takase, P Papst, N Terada, A C Nairn, Rapamycin inhibits ribosomal protein synthesis and induces G1 prolongation in mitogen-activated T lymphocytes. Journal of Immunology. ,vol. 155, pp. 3418- 3426 ,(1995)
Annalisa Leardi, Michele Caraglia, Carmine Selleri, Stefano Pepe, Claudia Pizzi, Rosario Notaro, Antonietta Fabbrocini, Sonya De Lorenzo, Manuela MusicÒ, Alberto Abbruzzese, Angelo Raffaele Bianco, Pierosandro Tagliaferri, Desferioxamine increases iron depletion and apoptosis induced by ara-C of human myeloid leukaemic cells. British Journal of Haematology. ,vol. 102, pp. 746- 752 ,(1998) , 10.1046/J.1365-2141.1998.00834.X