Human retroviruses in Amerindians of Colombia: high prevalence of human T cell lymphotropic virus type II infection among the Tunebo Indians.

摘要: The coexistence of infection with human T lymphotropic virus types I and II (HTLV-I HTLV-II) has been demonstrated recently among the Wayuu Indians from Guajira region Colombia. To ascertain if other Indian groups in Colombia are similarly infected, we tested 1,250 sera, collected between 1990 1992 18 culturally distinct Amerindian tribes living widely separated regions, for IgG antibodies against HTLV-I/II using enzyme-linked immunosorbent assay (ELISA) Western blot. Sera were also immunodeficiency 1 2 (HIV-1 HIV-2) to investigate overall burden retrovirus these semi-isolated indigenous groups. A total 33 samples repeatedly reactive antigens by ELISA, these, three sera Waunana/Noanama Choco area two Tunebo Santander found be infected HTLV-I HTLV-II, respectively, as verified blot differential ELISA. Thus, despite small sample size, seroprevalences HTLV-II 2.1% 5.0%, respectively. In contrast, none 29 who exhibited reactivity HIV-1/2 ELISA seropositive This study adds expanding list high prevalences infection. Further intensive investigations such populations will clarify natural history disease potential