Endemic versus epidemic viral spreads display distinct patterns of HTLV-2b replication

摘要: As the replication pattern of leukemogenic PTLVs possesses a strong pathogenic impact, we investigated HTLV-2 in vivo asymptomatic carriers belonging into 2 distinct populations infected by same HTLV-2b subtype. They include epidemically American blood donors, whom has been present for only 30 years, and endemically Bakola Pygmies from Cameroon, characterized long viral endemicity (at least few generations). In both circulating proviral loads degree cell proliferation were largely lower than those characterizing with (HTLV-1, STLV-1). This might contribute to explain lack known link between infection development malignancies this population. contrast, individuals displayed high resulting extensive cells. The route and/or duration infection, genetic drift, host immune response, background, co-infections or combination thereof have contributed these differences subjects. clonality observed is very reminiscent that at pre-leukemic stage, our results highlight possible oncogenic effect such