Methods and compositions for identifying subjects at risk of developing stent thrombosis

作者: Farouc Jaffer , Milind Rajopadhye

DOI:

关键词: SurgeryBlood vesselStentStent thrombosisAsymptomaticMedicineRadiology

摘要: The invention provides methods and compositions for determining whether a subject containing stent immobilized in blood vessel has asymptomatic thrombosis or is at risk of developing clinically symptomatic thrombosis. In one approach, the method involves imaging region that contains using probe fluorochrome, example, near-infrared targeting moiety binds molecular marker indicative presence development To extent displays more such markers, to markers increases local concentration vicinity stent. identifies those patients display higher density As result, can be monitored for, and/or treated prevent,

参考文章(76)
Antonio Colombo, Simon J. Corbett, Drug-eluting stent thrombosis: increasingly recognized but too frequently overemphasized. Journal of the American College of Cardiology. ,vol. 48, pp. 203- 205 ,(2006) , 10.1016/J.JACC.2006.04.040
Kevin Groves, Milind Rajopadhye, Biocompatible fluorescent metal oxide nanoparticles ,(2006)
Sarah E. M. Howie, Graham J. Cotton, Ian Heslop, Nicola J. Martin, David J. Harrison, Robert Ramage, Synthetic peptides representing discontinuous CD4 binding epitopes of HIV‐1 gp120 that induce T cell apoptosis and block cell death induced by gp120 The FASEB Journal. ,vol. 12, pp. 991- 998 ,(1998) , 10.1096/FASEBJ.12.11.991
Sylvie Kossodo, Karen N. Madden, Ella Jones, Kirtland G. Poss, Optical imaging probes ,(2003)
Michael Schirner, Martin Pessel, Kai Licha, Malte Bahner, Use of cyanine dyes for the diagnosis of proliferative diseases ,(2006)
Surender Kharbanda, Corinne Reimer, Mark Manfredi, W. Matthew Dickerson, Raghu Kalluri, Extracellular Matrix-derived Peptide Binds to αvβ3 Integrin and Inhibits Angiogenesis Journal of Biological Chemistry. ,vol. 276, pp. 31959- 31968 ,(2001) , 10.1074/JBC.M103024200
Michael Joner, Aloke V. Finn, Andrew Farb, Erik K. Mont, Frank D. Kolodgie, Elena Ladich, Robert Kutys, Kristi Skorija, Herman K. Gold, Renu Virmani, Pathology of Drug-Eluting Stents in Humans: Delayed Healing and Late Thrombotic Risk Journal of the American College of Cardiology. ,vol. 48, pp. 193- 202 ,(2006) , 10.1016/J.JACC.2006.03.042
Andreas Becker, Carsten Hessenius, Kai Licha, Bernd Ebert, Uwe Sukowski, Wolfhard Semmler, Bertram Wiedenmann, Carsten Grötzinger, Receptor-targeted optical imaging of tumors with near-infrared fluorescent ligands. Nature Biotechnology. ,vol. 19, pp. 327- 331 ,(2001) , 10.1038/86707