Role of K+ channel opening and Na+K+ ATPase activity in airway relaxation induced by salbutamol
作者： Jun Tamaoki , Etsuko Tagaya , Atsushi Chiyotani , Isao Yamawaki , Kimio Konno
DOI: 10.1016/0024-3205(94)90050-7
关键词: Ouabain 、 ATPase 、 Endocrinology 、 Apamin 、 Internal medicine 、 Potassium channel 、 Glibenclamide 、 Salbutamol 、 Charybdotoxin 、 Chemistry 、 Agonist
摘要: Abstract To determine the role of K + channel opening and Na K ATPase acitivity in β-adrenoceptor-mediated relaxation airway smooth muscle, we studied canine bronchial segments under isometric conditions vitro. Relaxant responses to salbutamol were not altered by glibenclamide or apamin but inhibited charybdotoxin, where significant inhibition was observed only at concentrations less than 10 −6 M. In contrast, relaxations induced 3 × M greater sensitive ouabain. Relaxations produced low high selectively attenuated charybdotoxin ouabain, respectively, a concentration-dependent manner. These results suggest that both Ca 2+ -activated may be operative β-adrenergic agonist, respectively.
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