Nitric Oxide in Human Skin: Current Status and Future Prospects

摘要: The gaseous free radical nitric oxide is an important biologic mediator with physiologic and pathophysiologic roles in nearly every organ system. Because of its unique activity, unusual chemical structure, unprecedented mechanisms action, oxide, arguably more than any other natural product, has opened new avenues to investigate cellular processes. Nitric generated tissues by specific synthases that metabolize arginine molecular oxygen citrulline oxide. Besides function as a diffusible messenger the vasculature neurons, also plays key role innate immunity inflammation. Recent progress allowed identification pathway several cell types reside skin, including keratinocytes, melanocytes, Langerhans cells, fibroblasts, endothelial cells. Convincing evidence suggests synthesis these cells can be modulated calcium-mobilizing agonists well diverse inflammatory immune stimuli, thereby contributes pathogenesis human skin diseases. Characterization intrinsic extrinsic regulatory stimuli afforded substantial insights into inflammatory, hyperproliferative, autoimmune diseases, cancer, may ultimately form basis for future therapeutic intervention. demonstrable potential disease treatment are subjects this review