Hydrazine derivatized cells

作者: Maria L. Thaler , Edward N. Granados , Daniel F. Heiman , Herbert S. Chow

DOI:

关键词: Combinatorial chemistryAgglutination (biology)AntibodyChromatographyCell membraneAntigenEpitopeHydrazideHydrazineCovalent bondChemistry

摘要: A method is provided for the preparation of semisolid particles or cells that have been chemically derivatized resulting in hydrazide functionalities covalently incorporated onto cell surface membrane molecules cells, as well a determining levels groups on cells. The involves and analysis red blood such manner molecules, hydrazine use thereof novel agglutination reactions to promote attachment antigens antibodies without loss antibody activity blocking epitope interest.