Carbohydrate-directed cross-linking reagents
作者： Avi J. Ashkenazi , Timothy P. Kogan , Steven M. Chamow
DOI:
关键词: Electrophile 、 Cross-Linking Reagents 、 Chemistry 、 Organic chemistry 、 Conjugated system 、 Hydrazide 、 Reagent 、 Maleimide 、 Residue (chemistry) 、 Nucleophile
摘要: The invention provides heterobifunctional cross-linking reagents and methods of using the reagents. combine a nucleophilic hydrazide residue with an electrophilic maleimide residue, allowing coupling aldehydes to free thiols. In invention, human immunodeficiency virus (HIV) infected cells can be detected conjugates that include CD4 molecules conjugated detectable markers via disclosed
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