Methods of treating bone disease using vascular endothelial growth factor fusion constructs

作者: Michael Rosenblum

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摘要: The 121-amino acid isoform of vascular endothelial growth factor (VEGF 121 ) is linked by a flexible G4S tether to cytotoxic molecule such as toxin gelonin or granzyme B and expressed soluble fusion protein. VEGF protein exhibits significant anti-tumor vascular-ablative effects that inhibit the primary tumors metastatic spread vascularization metastases. also target osteoclast precursor cells in vivo inhibits osteoclastogenesis.

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