Chronic biochemical cholestasis in patients receiving home parenteral nutrition: prevalence and predisposing factors.

作者: D. A. J. LLOYD , A. A. ZABRON , S. M. GABE

DOI: 10.1111/J.1365-2036.2008.03615.X

关键词: Risk factorEpidemiologyGastroenterologyPrevalenceIntensive care medicineMedicineMedical recordInternal medicineCholestasisBody mass indexParenteral nutritionLiver disease

摘要: Summary Background  Chronic biochemical cholestasis has been shown to be associated with a fivefold increase in histologically advanced liver disease patients receiving home parenteral nutrition. Aims  To investigate prevalence of chronic nutrition and examine factors influencing its occurrence. Methods  Records all for >6 months treated at single centre were reviewed plasma biochemistry recorded. Logistic regression analysis was employed identify cholestasis. Results  113 reviewed. The point 24%, increasing 28% if fluid electrolytes only excluded. In multivariate analysis, presence colon continuity significantly lower cholestasis, while total calorie intake higher cholestasis. No association seen between small intestinal lengths or lipid analysis. Conclusions  is common nutrition. High lack intestine are independently an increased risk

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