Evidence for altered control of glucose disposal after total colectomy.

摘要: Colonic fermentation of organic matter to short-chain fatty acids has been implicated in the improvement insulin sensitivity achieved by feeding diets rich complex carbohydrates. The present study assessed potential role colon determining postprandial glucose kinetics. Metabolic responses a complex-carbohydrate test meal were determined conjunction with primed continuous infusion D-[6,6- 2 H]glucose group ileostomists and sex-matched controls. Glucose disposal (GD) was computed using Steele's (1959) non-steady-state kinetics on single compartment model. Insulin derived cumulative GD as dependent variable, time integrated concentration independent variables. ileostomist had significantly higher plasma (P = 0.034) compared control group, but no difference concentration. Total similar each although insulin-dependent substantially lower (0.46 v. 0.13 mg glucose/min per pmol, P 0.015), also showed 50 % rate oxidation period 0.005), non-oxidative not affected. indicates that loss is associated several characteristics resistance syndrome, favours view glucose.