Metabolic cross talk between the colon and the periphery: implications for insulin sensitivity

摘要: Until recently, a glance at standard undergraduate textbook would have given the impression that colon was merely storage organ for faeces and maybe something about absorption of electrolytes water. In reality, is highly-metabolically-active organ, function which has implications not only remainder digestive tract, but also peripheral organs such as adipose tissue (AT), liver skeletal muscle. The present review focuses on two distinct complementary areas: (1) metabolic adaptation occurs following surgical removal colonic tissue; (2) effect modulating in situ terms postprandial metabolism, insulin sensitivity disease risk. Work these areas points to being important normal sensitivity. role fatty acids central hypothesis. AT acts daily 'buffer' acids. However, resection there an apparent change function. There increase lipolysis rate, resulting release excess into circulation consequently take up This resultant either lipid or its oxidation result reduction insulin-sensitising effects high-fibre diets are related changes acid manipulating allows mechanisms be elucidated. research area exciting one, involving potential SCFA (the absorbed by-products bacterial fermentation) acting directly tissues, recent identification G-protein-coupled receptors specific ligands.