Novel use of somatostatin receptor scintigraphy in localization of focal congenital hyperinsulinism: promising but fallible.
作者： S Dutta , S. Venkataseshan , C. Bal , K.L N. Rao , K. Gupta
DOI: 10.1515/JPEM.2009.22.10.965
关键词: Somatostatin receptor scintigraphy 、 Congenital hyperinsulinism 、 Hypoglycemia 、 Histopathology 、 Medicine 、 Pancreas 、 Scintigraphy 、 Somatostatin Analogue 、 In patient 、 Pathology
摘要: Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycemia in infants and children. The pre-operative differentiation focal from diffuse forms extremely important management point view. current methods for are invasive. We report a patient with CHI where somatostatin receptor scintigraphy was used to diagnose but limited success. A preoperative 68 gallium DOTATOC-PET scan performed which revealed highly localized radiotracer uptake body pancreas. 80% pancreas including resected. clinical problems did not completely resolve after surgery. Histopathology hyperplastic islet cells at resected margin randomly throughout This case highlights use severe CHI. satellite foci that were missed may be either an inherent limitation Ga DOTATOC or underinterpretation due lack expertise. opens up new option using analogue localization patients
sci-hub.se 参考文章(15)
R. Lebtahi, D. Le Guludec, L. Sarda, D. Daou, Y. Petegnief, M. Mignon, M. Faraggi, G. Cadiot, Clinical Impact of Somatostatin Receptor Scintigraphy in the Management of Patients with Neuroendocrine Gastroenteropancreatic Tumors The Journal of Nuclear Medicine. ,vol. 38, pp. 853- 858 ,(1997)
Olga T. Hardy, Miguel Hernandez-Pampaloni, Janet R. Saffer, Mariko Suchi, Eduardo Ruchelli, Hongming Zhuang, Arupa Ganguly, Richard Freifelder, N. Scott Adzick, Abass Alavi, Charles A. Stanley, Diagnosis and Localization of Focal Congenital Hyperinsulinism by 18F-Fluorodopa PET Scan The Journal of Pediatrics. ,vol. 150, pp. 140- 145 ,(2007) , 10.1016/J.JPEDS.2006.08.028
Anders Sundin, Ulrike Garske, Håkan Örlefors, Nuclear imaging of neuroendocrine tumours. Best Practice & Research Clinical Endocrinology & Metabolism. ,vol. 21, pp. 69- 85 ,(2007) , 10.1016/J.BEEM.2006.12.003
Jörg Kowalski, Marcus Henze, Jochen Schuhmacher, Helmut R Mäcke, Michael Hofmann, Uwe Haberkorn, Evaluation of Positron Emission Tomography Imaging Using [68Ga]-DOTA-D Phe1-Tyr3-Octreotide in Comparison to [111In]-DTPAOC SPECT. First Results in Patients with Neuroendocrine Tumors Molecular Imaging and Biology. ,vol. 5, pp. 42- 48 ,(2003) , 10.1016/S1536-1632(03)00038-6
P de Lonlay, J C Fournet, J Rahier, M S Gross-Morand, F Poggi-Travert, V Foussier, J P Bonnefont, M C Brusset, F Brunelle, J J Robert, C Nihoul-Fékété, J M Saudubray, C Junien, Somatic deletion of the imprinted 11p15 region in sporadic persistent hyperinsulinemic hypoglycemia of infancy is specific of focal adenomatous hyperplasia and endorses partial pancreatectomy. Journal of Clinical Investigation. ,vol. 100, pp. 802- 807 ,(1997) , 10.1172/JCI119594
A Aynsley-Green, K Hussain, J Hall, JM Saudubray, C Nihoul-Fekete, P De Lonlay-Debeney, F Brunelle, T Otonkoski, P Thornton, KJ Lindley, Practical management of hyperinsulinism in infancy Archives of Disease in Childhood-fetal and Neonatal Edition. ,vol. 82, ,(2000) , 10.1136/FN.82.2.F98
F. Brunelle, V. Negre, M. O. Barth, C. N. Fekete, P. Czernichow, J. M. Saudubray, F. Kuntz, T. Tach, D. Lallemand, Pancreatic venous samplings in infants and children with primary hyperinsulinism. Pediatric Radiology. ,vol. 19, pp. 100- 103 ,(1989) , 10.1007/BF02387895
Guido Rindi, Carlo Capella, E. Solcia, Cell biology, clinicopathological profile, and classification of gastro-enteropancreatic endocrine tumors. Journal of Molecular Medicine. ,vol. 76, pp. 413- 420 ,(1998) , 10.1007/S001090050233
Shankar Vallabhajosula, (18)F-labeled Positron Emission Tomographic Radiopharmaceuticals in Oncology: An Overview of Radiochemistry and Mechanisms of Tumor Localization Seminars in Nuclear Medicine. ,vol. 37, pp. 400- 419 ,(2007) , 10.1053/J.SEMNUCLMED.2007.08.004
Dik J. Kwekkeboom, Willem H. Bakker, Eric P. Krenning, Helmut R. Mäcke, Peter P. Kooij, Comparison of 111In-DOTA-Tyr3-octreotide and 111In-DTPA-octreotide in the same patients: biodistribution, kinetics, organ and tumor uptake. The Journal of Nuclear Medicine. ,vol. 40, pp. 762- 767 ,(1999)