Targeting DNA damage response: Threshold, chromatin landscape and beyond
DOI: 10.1016/J.PHARMTHERA.2012.12.006
关键词: DNA damage 、 Chromatin 、 Chromatin remodeling 、 Cell biology 、 Biology 、 DNA repair 、 DNA re-replication 、 MDC1 、 DNA mismatch repair 、 Genetics 、 Histone
摘要: Cells are continually exposed to DNA assaults from exogenous and endogenous sources. To maintain genomic integrity, cells have evolved a highly conserved mechanism for repairing lesions and, in particular, double strand breaks (DSBs). Emerging evidence indicates that repair/signaling machinery acts an integrated fashion with chromatin structure at damaged sites. This review focuses on the interplay between histone modifications chromatin-mediated response damage.
core.ac.uk
elsevier.com
sci-hub.se 参考文章(124)
Yingli Sun, Xiaofeng Jiang, Ye Xu, Marina K. Ayrapetov, Lisa A. Moreau, Johnathan R. Whetstine, Brendan D. Price, Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60. Nature Cell Biology. ,vol. 11, pp. 1376- 1382 ,(2009) , 10.1038/NCB1982
Andrew J. Bannister, Philip Zegerman, Janet F. Partridge, Eric A. Miska, Jean O. Thomas, Robin C. Allshire, Tony Kouzarides, Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature. ,vol. 410, pp. 120- 124 ,(2001) , 10.1038/35065138
Darryll D. Dudley, Jayanta Chaudhuri, Craig H. Bassing, Frederick W. Alt, Mechanism and Control of V(D)J Recombination versus Class Switch Recombination: Similarities and Differences Advances in Immunology. ,vol. 86, pp. 43- 112 ,(2005) , 10.1016/S0065-2776(04)86002-4
Simona Negrini, Vassilis G. Gorgoulis, Thanos D. Halazonetis, Genomic instability — an evolving hallmark of cancer Nature Reviews Molecular Cell Biology. ,vol. 11, pp. 220- 228 ,(2010) , 10.1038/NRM2858
Irene M. Ward, Junjie Chen, Histone H2AX Is Phosphorylated in an ATR-dependent Manner in Response to Replicational Stress Journal of Biological Chemistry. ,vol. 276, pp. 47759- 47762 ,(2001) , 10.1074/JBC.C100569200
Haico van Attikum, Susan M. Gasser, The histone code at DNA breaks: a guide to repair? Nature Reviews Molecular Cell Biology. ,vol. 6, pp. 757- 765 ,(2005) , 10.1038/NRM1737
Kyu Heo, Hyunjung Kim, Si Ho Choi, Jongkyu Choi, Kyunghwan Kim, Jiafeng Gu, Michael R. Lieber, Allen S. Yang, Woojin An, FACT-Mediated Exchange of Histone Variant H2AX Regulated by Phosphorylation of H2AX and ADP-Ribosylation of Spt16 Molecular Cell. ,vol. 30, pp. 86- 97 ,(2008) , 10.1016/J.MOLCEL.2008.02.029
Paul B. Talbert, Steven Henikoff, Histone variants — ancient wrap artists of the epigenome Nature Reviews Molecular Cell Biology. ,vol. 11, pp. 264- 275 ,(2010) , 10.1038/NRM2861
Helle D. Ulrich, Helen Walden, Ubiquitin signalling in DNA replication and repair Nature Reviews Molecular Cell Biology. ,vol. 11, pp. 479- 489 ,(2010) , 10.1038/NRM2921
S. Keeney, M.J. Neale, Initiation of meiotic recombination by formation of DNA double-strand breaks: mechanism and regulation Biochemical Society Transactions. ,vol. 34, pp. 523- 525 ,(2006) , 10.1042/BST0340523