Chiron 800 System CO-oximeter Module Overestimates Methemoglobin Concentrations in Neonatal Samples Containing Fetal Hemoglobin
作者： Patrick L M Lynch , David E Bruns , James C Boyd , John Savory
DOI: 10.1093/CLINCHEM/44.7.1569
关键词: CO-oximeter 、 Chemistry 、 Quantitative analysis (chemistry) 、 Toxicity 、 Hemoglobin 、 Nitric oxide 、 Methemoglobin 、 Surgery 、 Fetal hemoglobin 、 Persistent pulmonary hypertension 、 Endocrinology 、 Internal medicine
摘要: Inhaled nitric oxide (NO) is an established treatment for persistent pulmonary hypertension of the newborn (1). NO can oxidize erythrocyte hemoglobin Fe(II) to Fe(III), however, and lead potentially toxic accumulation methemoglobin (MetHb) (2). Because MetHb fractions >5% toxicity, monitoring throughout therapy required. In one exceptional case, excessive dosing led a fraction 40% (3). neonatal blood contains high proportion fetal (HbF), typically 75–90% at term (4), accurate measurement in presence HbF essential. We wished ascertain accuracy determination by Chiron 800 system CO-oximeter module (Chiron Diagnostics), part their 865 analyzer, HbF. A similar study …
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