The postnatal decline of hemoglobin F synthesis in normal full-term infants.
作者： H Bard
DOI: 10.1172/JCI107943
关键词:
摘要: Studies were carried out during the 1st yr of life in normal infants born at term to determine proportions fetal hemoglobin (Hb F) and adult A) being synthesized, order describe complete switchover from Hb F A synthesis postnatal life. 53 blood samples 37 incubated an amino acid mixture containing [14C]leucine chromatographed on DEAE-Sephadex for separation fractions. The completeness CEAE-Sephadex age when major portion was type confirmed by globin chain chromatography with use carboxylmethyl cellulose. There a rapid decline postnatally until 16-20 wk levels 3.2% plus or minus SD 2.1% reached. By combining this data that previously published, can be described humans relation postconceptional age. It follows sigmoid curve; steep portion, which lies between 30th 52nd week, is preceded follwoed plateaus averaging 95% 7% synthesis, respectively.
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