Endpoints of spermatotoxicity in the rat after short duration exposures to fourteen reproductive toxicants

摘要: Multiple endpoints of spermatotoxicity in short duration tests (1-5 days exposure; 2.5-week assay interval) were investigated a number chemicals reported to produce minimal severe reproductive effects when administered subchronically. Six these (boric acid, dinoseb, 2,5-hexanedione, methoxychlor, metronidazole, ornidazole) produced substantial after 1 5 doses. Spermatotoxic chlordimeform equivocal while p,p'-DDT, n-hexane, and sodium chlorite judged negative. Four with known acute (benomyl, busulfan, ethylene glycol monomethyl ether, nitrobenzene) elicited expected histopathologic responses single dose. Testicular histology, testicular sperm head counts, cauda morphology, velocity proved be the most toxicologically sensitive one or more studies, but histopathology testis epididymis was consistent indicator damage. The percentage motile concentration epididymal fluid least measurements. data suggested that potential moderate damage are detectable test. Complementary multiple enhanced interpretation results, often identified cellular targets, provided insight on possible mechanisms. Specific similar specific for subchronic exposures. A test could value as screen structure-activity studies set priorities requiring further evaluation. As supplement breeding generated also used enhance design longer tests.