Peptide and protein drug delivery

摘要: "Fundamentals Changing Needs in Drug Delivery the Era of Peptide and Protein Drugs Synthesis Peptides Proteins by Chemical Biotechnological Means Physical Biochemistry Drugs: Structure, Properties, Stabilities Compared with Analysis Enzymatic Barriers Intestinal Epithelial Vascular Endothelial to Pharmacokinetics Pharmacodynamics Routes Parenteral Nasal Route Buccal Oral Rectal Vaginal Transdermal Practical Considerations Preformulation Formulation Case History an LHRH Analog Mucosal Dosage Forms for Controlled Systems Characterization Toxicity Profile Therapeutics Reduction Immunogenicity Extension Circulating Half-Life Regulatory Perspective Development "