Systematic review and meta-analysis of incidence and correlates of recurrence of takotsubo cardiomyopathy.

摘要: Abstract Aim Takotsubo cardiomyopathy (TTC) is a disorder of myocardial inflammation induced by high catecholamine levels and associated with acute complications. In the long-term TTC risk single or multiple recurrences, but such occurrences not clear. We performed systematic review meta-analysis to identify consolidate evidence on incidence clinical correlates cases recurrence. Methods A comprehensive search four major databases (EMBASE, OVID Medline, PubMed Google Scholar) was from their inception first week Jan 2014. included original research studies, recruiting ≥5 participants, ≥3months follow-up, published in English language that reported data recurrence patients TTC. Results Out 298 studies searched, 31 cohorts (1664 patients) were analyses. 74 recurrence, mean follow-up 24.5months (95% CI, 19.3 33months), extensive available for 23 cases. Cumulative approximately 5% at 6years. Annual rate 1.5%. Furthermore, 14% had recurrent chest pain 11% dyspnea without definite Discharge medications index admission β-adrenoceptor antagonists (BB) 66.8% ACE inhibitors (ACEi) ARB 67.4%. Recurrence independent clinic utilization BB prescription, inversely correlated ( r =−0.45, p =0.016) ACEi/ARB prescription. Patients severe noted have more recurrences. Conclusions (1) only 1–2% annual substantially greater frequency ongoing symptoms. (2) rather than may reduce