The AF64A model of cholinergic hypofunction: An update

摘要: Based on numerous reports in the literature since 1980, one can now conclude that ethylcholine aziridinium (AF64A) is selective for cholinergic system vivo, and effect both dose- site-dependent. Thus, AF64A treatment, under correct conditions of dose time will result reductions levels ACh, AChE, ChAT, HAChT, K+- ouabainstimulated release ACh. While other neurotransmitters may also be affected brains treated rats, only transient most probably secondary to initial deficit induced by AF64A, reflecting an adaptive reaction these neurotransmitter systems, which are normally integrated with interconnections, deficiency AF64A. This paper provides a historical perspective development as cholinotoxin, surveys its potential mechanisms action at neurochemical molecular levels. Moreover, availability animal model such AF64A-treated rat, has been compromised selectively extended period time, allowed investigators study wide variety questions relate factors controlling function vivo. Several key illustrations presented end this paper.