In vivo imaging of microglial activation with [11C](R)-PK11195 PET in progressive supranuclear palsy.
作者： Alexander Gerhard , Iris Trender-Gerhard , Federico Turkheimer , Niall P. Quinn , Kailash P. Bhatia
DOI: 10.1002/MDS.20668
关键词: Basal ganglia 、 Pathology 、 Corticobasal degeneration 、 Brainstem 、 Cerebellum 、 Progressive supranuclear palsy 、 Neuroglia 、 Medicine 、 Parkinsonism 、 Frontal lobe
摘要: Progressive supranuclear palsy (PSP) is a neurodegenerative disease presenting with voluntary gaze difficulties, early falls, and Parkinsonism. Neuronal loss, associated intracellular neurofibrillary tangles activated microglia, found targeting the basal ganglia, brainstem nuclei, frontal cortex. [(11)C](R)-PK11195 PET marker of peripheral benzodiazepine binding sites (PBBS) expressed by microglia. We have used to demonstrate in vivo degree distribution glial response degenerative process four patients PSP. Compared normal age-matched controls, PSP patient group showed significantly increased mean midbrain, lobe, cerebellum. Two were rescanned after 6 10 months during that time level microglial activation remained stable. reveals pattern involving cortical subcortical regions corresponds well known neuropathological changes. PET, therefore, may help characterizing underlying activity (c) 2005 Movement Disorder Society.
manchester.ac.uk参考文章(18)
R. B BANATI, R MYERS, G. W KREUTZBERG, PK (‘peripheral benzodiazepine’) – binding sites in the CNS indicate early and discrete brain lesions: microautoradiographic detection of [3H]PK 11195 binding to activated microglia Journal of Neurocytology. ,vol. 26, pp. 77- 82 ,(1997) , 10.1023/A:1018567510105
Richard A. Robb, Dennis P. Hanson, A software system for interactive and quantitative visualization of multidimensional biomedical images. Australasian Physical & Engineering Sciences in Medicine. ,vol. 14, pp. 9- 30 ,(1991)
Marshal F. Folstein, Susan E. Folstein, Paul R. McHugh, “Mini-mental state” Journal of Psychiatric Research. ,vol. 12, pp. 189- 198 ,(1975) , 10.1016/0022-3956(75)90026-6
T J Spinks, T Jones, P M Bloomfield, D L Bailey, M Miller, D Hogg, W F Jones, K Vaigneur, J Reed, J Young, D Newport, C Moyers, M E Casey, R Nutt, Physical characteristics of the ECAT EXACT3D positron tomograph. Physics in Medicine and Biology. ,vol. 45, pp. 2601- 2618 ,(2000) , 10.1088/0031-9155/45/9/313
Donald R Royall, The FAB A frontal assessment battery at bedside Neurology. ,vol. 55, pp. 1621- 1626 ,(2000) , 10.1212/WNL.55.11.1621
Colin Studholme, Derek L. G. Hill, David J. Hawkes, Automated three-dimensional registration of magnetic resonance and positron emission tomography brain images by multiresolution optimization of voxel similarity measures Medical Physics. ,vol. 24, pp. 25- 35 ,(1997) , 10.1118/1.598130
JOHN C. STEELE, Progressive Supranuclear Palsy: A Heterogeneous Degeneration Involving the Brain Stem, Basal Ganglia and Cerebellum With Vertical Gaze and Pseudobulbar Palsy, Nuchal Dystonia and Dementia JAMA Neurology. ,vol. 10, pp. 333- 359 ,(1964) , 10.1001/ARCHNEUR.1964.00460160003001
David J Burn, Andrew J Lees, Progressive supranuclear palsy: where are we now? Lancet Neurology. ,vol. 1, pp. 359- 369 ,(2002) , 10.1016/S1474-4422(02)00161-8
J. Gray Chickering, Alan J. Sokoloff, Innervation of propatagial musculature in a flying squirrel, Glaucomys volans (Rodentia, Sciuridae). Brain Behavior and Evolution. ,vol. 47, pp. 1- 7 ,(1996) , 10.1159/000113224
Roger N. Gunn, Adriaan A. Lammertsma, Susan P. Hume, Vincent J. Cunningham, Parametric Imaging of Ligand-Receptor Binding in PET Using a Simplified Reference Region Model NeuroImage. ,vol. 6, pp. 279- 287 ,(1997) , 10.1006/NIMG.1997.0303