Mammary tumor phenotypes in wild-type aging female FVB/N mice with pituitary prolactinomas.
作者： E. Radaelli , A. Arnold , A. Papanikolaou , R. A. Garcia-Fernandez , S. Mattiello
DOI: 10.1354/VP.08-VP-0280-R-FL
关键词: Pituitary tumors 、 Mammary tumor 、 Histopathology 、 Prolactin 、 Biology 、 Pathology 、 Immunohistochemistry 、 Carcinogenesis 、 Adenocarcinoma 、 Adenoma
摘要: Prolactin-secreting pituitary adenomas are common spontaneous lesions in aging FVB females. proliferations play a significant role mouse mammary tumorigenesis generally producing adenosquamous carcinomas. Since genetically engineered mice frequently used to study tumor biology, we have examined cohort of 64 wild-type FVB/N females establish the prevalence and nature tumors. Tissues from glands were studied by histopathology immunohistochemistry. Of mice, 20 had tumors Mammary associated 17 mice. All prolactin-positive immunohistochemistry classified as prolactinomas. Fourteen tumors, including 12 cases with 2 without concurrent prolactinomas, adenocarcinomas different combinations epithelial growth patterns. Five prolactinomas mammar...
sagepub.com
elsevier.com
cabdirect.org
sci-hub.se 参考文章(38)
K. Miyoshi, J. M. Shillingford, F. Le Provost, F. Gounari, R. Bronson, H. von Boehmer, M. M. Taketo, R. D. Cardiff, L. Hennighausen, K. Khazaie, Activation of β-catenin signaling in differentiated mammary secretory cells induces transdifferentiation into epidermis and squamous metaplasias Proceedings of the National Academy of Sciences of the United States of America. ,vol. 99, pp. 219- 224 ,(2002) , 10.1073/PNAS.012414099
Lêda S. Felicio, James F. Nelson, Caleb E. Finch, Spontaneous pituitary tumorigenesis and plasma oestradiol in ageing female C57BL/6J mice Experimental Gerontology. ,vol. 15, pp. 139- 143 ,(1980) , 10.1016/0531-5565(80)90085-6
Karl Willert, Katherine A Jones, Wnt signaling: is the party in the nucleus? Genes & Development. ,vol. 20, pp. 1394- 1404 ,(2006) , 10.1101/GAD.1424006
Jennifer H Gutzman, Kristin K Miller, Linda A Schuler, Endogenous human prolactin and not exogenous human prolactin induces estrogen receptor α and prolactin receptor expression and increases estrogen responsiveness in breast cancer cells The Journal of Steroid Biochemistry and Molecular Biology. ,vol. 88, pp. 69- 77 ,(2004) , 10.1016/J.JSBMB.2003.10.008
Eunice L. Kwak, Sang Kim, Jianmin Zhang, Robert D. Cardiff, Emmett V. Schmidt, Daniel A. Haber, Mammary Tumorigenesis following Transgenic Expression of a Dominant Negative CHK2 Mutant Cancer Research. ,vol. 66, pp. 1923- 1928 ,(2006) , 10.1158/0008-5472.CAN-05-1237
Robert D. Cardiff, Andrea Rosner, Michael A. Hogarth, Jose J. Galvez, Alexander D. Borowsky, Jeffrey P. Gregg, Validation: the new challenge for pathology. Toxicologic Pathology. ,vol. 32, pp. 31- 39 ,(2004) , 10.1080/01926230490424662
Kay-Uwe Wagner, Models of breast cancer: quo vadis, animal modeling? Breast Cancer Research. ,vol. 6, pp. 31- 38 ,(2003) , 10.1186/BCR723
Sandip K. Mishra, Amjad H. Talukder, Anupama E. Gururaj, Zhibo Yang, Rajesh R. Singh, My G. Mahoney, Clara Francí, Ratna K. Vadlamudi, Rakesh Kumar, Upstream determinants of estrogen receptor-α regulation of metastatic tumor antigen 3 pathway Journal of Biological Chemistry. ,vol. 279, pp. 32709- 32715 ,(2004) , 10.1074/JBC.M402942200
Janan T Eppig, John P Sundberg, Igor Mikaelian, Natalie Blades, Gary A Churchill, Karen Fancher, Barbara B Knowles, Proteotypic classification of spontaneous and transgenic mammary neoplasms Breast Cancer Research. ,vol. 6, pp. 1- 12 ,(2004) , 10.1186/BCR930
Grazia Arpino, Heidi Weiss, Adrian V. Lee, Rachel Schiff, Sabino De Placido, C. Kent Osborne, Richard M. Elledge, Estrogen Receptor–Positive, Progesterone Receptor–Negative Breast Cancer: Association With Growth Factor Receptor Expression and Tamoxifen Resistance Journal of the National Cancer Institute. ,vol. 97, pp. 1254- 1261 ,(2005) , 10.1093/JNCI/DJI249