Natural almond skin reduced oxidative stress and inflammation in an experimental model of inflammatory bowel disease.
作者： Giuseppina Mandalari , Carlo Bisignano , Tiziana Genovese , Emanuela Mazzon , Martin S.J. Wickham
DOI: 10.1016/J.INTIMP.2011.02.003
关键词: Intracolonic 、 Immunology 、 Pharmacology 、 Nitrotyrosine 、 Inflammatory bowel disease 、 Chemistry 、 Inflammation 、 Diarrhea 、 Oxidative stress 、 Colitis 、 Myeloperoxidase
摘要: The aim of the present study was to examine effects natural almond skin (NS) powder in mice subjected experimental colitis. Colitis induced by intracolonic instillation dinitrobenzene sulfonic acid (DNBS). NS administered daily orally (30 mg/kg). Four days after DNBS administration, colon NF-κB and p-JNK activation increased as well TNF-α IL-1β productions. Neutrophil infiltration, myeloperoxidase (MPO) activity, mucosa associated with up-regulation ICAM-1 P-selectin. Immunohistochemistry for i-NOS, nitrotyrosine poly (ADP-ribose) polymerase (PARP) showed an intense staining inflamed colon. Treatment significantly reduced appearance diarrhea body weight loss. This a significant reduction colonic MPO activity. also activation, pro-inflammatory cytokines release, PARP expression results this suggested that administration may be beneficial treatment inflammatory bowel disease.
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