The impact of sex on risk of cardiovascular disease and all-cause mortality in adults with or without diabetes mellitus: A comparison between the U.S. and Japan
作者： Longjian Liu , Katsuyuki Miura , Aya Kadota , Akira Fujiyoshi , Edward J. Gracely
DOI: 10.1016/J.JDIACOMP.2019.03.008
关键词: Heart disease 、 Risk of mortality 、 Cohort 、 Medicine 、 Internal medicine 、 Disease 、 Relative risk 、 Hazard ratio 、 Stroke 、 Diabetes mellitus
摘要: Abstract Aims To test a hypothesis that women with diabetes mellitus (DM) versus those without DM had significantly higher risk of heart disease (HD), stroke and all-cause mortality than their male counterparts in the U.S. as well Japan. Methods We analyzed two nationally representative datasets, one from NHANES III cohort (n = 13,169), other Japan NIPPON DATA90 (n = 7445). Hazard ratios (HRs) for sex-DM interaction effect on were prospectively using Cox's proportional hazards regression models. Results Patients HD, However, HRs non-DM HD compared to men (sex-DM interaction: HR = 1.59, p = 0.01, 1.24, p = 0.045 mortality), but was not statistically significant Japanese cohort. Discussion relative U.S, this sex difference by status observed Whether sex-difference is due metabolic disorders between populations warrants consideration further studies.
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