Small Nucleolar RNAs: Identification, Structure, and Function

摘要: The revelation in the last few years of a large number new noncoding RNAs (ncRNAs) has revolutionized our view how gene regulation works. This is to extent due recent advances computational as well experimental methodology, combined with an increasing sequenced genomes which have had enormous impact on quest for small ncRNAs. These function per se and are not merely intermediates transfer information from genes proteins. Instead they turned out be involved many complex biological processes, including stress response, cell differentiation, even control diseases. chapter briefly describes some methods used identify isolate different classes ncRNAs size range 50–500 nt. One these, nucleolar RNAs, will discussed detail.