Genetic Polymorphisms of Pharmacogenomic VIP Variants in the Circassian Subpopulation from Jordan.

摘要: BACKGROUND It has been suggested that genetic variation within candidate pharmacogenes contributes to the differences in drug safety and efficacy as well risk of adverse reactions among different ethnic groups. Illustrating polymorphic distribution Very Important Pharmacogenes (VIPs) various groups will contribute development personalized medicine for those populations. OBJECTIVE The present study aimed identify VIPs Circassian subpopulation Jordan compare their allele frequencies with other METHODS A total 130 healthy unrelated adults from were randomly recruited genotyped eleven VIP variants thiopurine S-methyltransferase (TPMT), ATP-binding cassette, sub-family B, member 1 (ABCB1), vitamin D receptor (VDR) genes via Sequenom's MassARRAY® genotyping platform (iPLEX GOLD). RESULTS Our data on allelic investigated compared 18 populations, comprising 11 HapMap 6 Exome Aggregation Consortium Chechen- Jordanian population Jordan. Circassian-Jordanians found most resemble African, Jordanian, European (Finnish), (non-Finnish), South-Asian CONCLUSION Circassians significantly differ populations terms selected variants. findings constitute first set pharmacogenetic Jordan, providing a basis safe administration may be useful diagnosing treating diseases this group.