Eukaryotic chromosome DNA replication: where, when, and how?
作者： Hisao Masai , Seiji Matsumoto , Zhiying You , Naoko Yoshizawa-Sugata , Masako Oda
DOI: 10.1146/ANNUREV.BIOCHEM.052308.103205
关键词: Genetics 、 Origin recognition complex 、 Biology 、 DNA replication 、 Licensing factor 、 Eukaryotic DNA replication 、 Computational biology 、 Origin of replication 、 Control of chromosome duplication 、 Pre-replication complex 、 Semiconservative replication
摘要: DNA replication is central to cell proliferation. Studies in the past six decades since proposal of a semiconservative mode have confirmed high degree conservation basic machinery from prokaryotes eukaryotes. However, need for substantially longer segment coordination with various internal and external signals eukaryotic cells has led more complex versatile regulatory strategies. The program higher eukaryotes under dynamic plastic regulation within single cell, or population, during development. We review here mechanisms that control discuss future directions this field.
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