Hesperetin impairs glucose uptake and inhibits proliferation of breast cancer cells

摘要: The flavanone hesperetin is known to decrease basal glucose uptake, although the inhibitory mechanism largely unknown. Here, we used MDA-MB-231 breast cancer cells investigate molecular pathways affected by hesperetin. results indicate that suppression of uptake caused down-regulation transporter 1 (GLUT1). Hesperetin was also found inhibit insulin-induced through impaired cell membrane translocation 4 (GLUT4). In addition, phosphorylation insulin receptor-beta subunit (IR-beta) and Akt suppressed. decreased cellular proliferation, which likely due inhibition uptake. Cancer are highly dependent on may, therefore, have potential application as an anticancer agent.