Determination and characterization of hexokinase in thyroid cancer and benign neoplasms.

摘要: Hexokinase (ADP: D-hexose-6-phosphotransferase, EC 2.7.1.1) was studied in human thyroid carcinomas (n = 11), follicular adenomas 32), and normal tissue 21). The specific activity significantly increased carcinoma (0.163 +/- 0.083 U/mg protein) compared with (0.030 0.010 (P less than 0.001). Specific activities of are rather heterogeneous, but when subdivided into three groups according to histopathologic criteria, a significant difference found between group I II III. A lesser cellular differentiation is indicated by the lower degree or even absence colloid production follicle formation. higher proliferation rate may be assumed on grounds irregularities outline, often defective pseudocapsule, signs compression surrounding tissue. highest proliferative activity, i.e., III, whereas lowest were grade proliferation, I; former comparable values latter An interesting compartmentation hexokinase different differentiation. In papillary proportion (HK) present cytosol comparison undifferentiated carcinomas. more HK contrast isozyme composition not from