Xenon and the inflammatory response to cardiopulmonary bypass in the rat.
作者： Jeffrey A. Clark , Daqing Ma , H. Mayumi Homi , Mervyn Maze , Hilary P. Grocott
DOI: 10.1053/J.JVCA.2005.05.007
关键词: Inflammatory response 、 Oxygenator 、 Anesthesia 、 Xenon 、 Medicine 、 Surgical preparation 、 Cardiopulmonary bypass
摘要: Objective: The purpose of this study was to investigate the effect xenon on inflammatory response cardiopulmonary bypass. Design: Prospective, randomized experimental study. Setting: University research laboratory. Participants: Sprague-Dawley rats. Interventions: After surgical preparation, rats were randomly divided into 4 groups: (1) SHAM cannulated but did not undergo bypass; (2) bypass subjected 60 minutes using an oxygenator receiving a 30% O 2 , 65% N and 5% CO gas mixture; (3) MK801 received (0.15 mg/kg intravenous) 15 before with same (4) underwent 60% xenon, mixture. Measurements Main Results: All groups showed elevations in both cytokines compared SHAM-operated group. However, group no different from other groups. Conclusions: Xenon appears have bypass, making its previously described neuroprotective during likely independent any inflammation modulation.
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