Role of adipokines and cytokines in obesity-associated breast cancer: therapeutic targets.
作者： Sajid Khan , Samriddhi Shukla , Sonam Sinha , Syed Musthapa Meeran
DOI: 10.1016/J.CYTOGFR.2013.10.001
关键词: SOCS3 、 Cancer research 、 Breast cancer 、 Insulin 、 Biology 、 Sex hormone-binding globulin 、 Leptin 、 Tumor microenvironment 、 Adiponectin 、 Adipokine 、 Endocrinology 、 Internal medicine
摘要: Obesity is the cause of a large proportion breast cancer incidences and mortality in post-menopausal women. In obese people, elevated levels various growth factors such as insulin insulin-like (IGFs) are found. Elevated level leads to increased secretion estrogen by binding circulating sex hormone globulin (SHBG). The estrogen-mediated downstream signaling favors carcinogenesis. altered expression profiles adipokines cytokines including leptin, adiponectin, IL-6, TNF-α IL-1β. leptin decreased adiponectin directly associated with development. Increased pro-inflammatory within tumor microenvironment promote Efficacy available drugs against obesity-associated yet be confirmed. this review, we will discuss different adipokine- cytokine-mediated molecular pathways involved cancer, therapeutic strategies potential targets for cancer.
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