Signal Transduction Issues in Studies of Human Basophils and Mast Cells

摘要: In humans, there are now known to be several types of cells which bear FceeRI. The list currently includes mast cells, basophils, monocytes,1 Langerhans cells,2 and eosinophils3 (unpublished reports epithileal also). Of these, expression on eosinophils appears controversial with only one laboratory supporting this possibility; however, the functional consequences FceRI aggregation monocytes is also not yet entirely clear. addition, it that may composed α γ subunits, significance On other hand, cell basophil representative secrete in response these clearly play a number roles various diseases. Understanding nature signal transduction apparatus exists basophils will have ready application developing new therapies for treatment diseases like atopy asthma. Mast readily obtainable numbers or purities allow easy discovery underlying mechanisms. This type work best accomplished either human animal lines. Nevertheless, quite clear development some succeed when function normal understood. A good example how their counterpart can found effort 1970s develop potent analogs cromolyn. An enormous by pharmaceutical industry drugs inhibited rat FceRI-mediated release high potency efficacy were ineffective humans. While cromolyn used today physicians allergic conditions, mechanism its actions don’t revolve around inhibition, but remain unknown weak moderate effects at best. lesson seems drug should well integrated studies basophils. Apparently, precise details mechanisms vary enough among bearing all approaches translate types. These issues discussed against backdrop information derived from extensive both RBL-2H3 peritoneal lines cells.