Pitfalls in the Serological Diagnosis of Primary Human Cytomegalovirus Infection in Pregnancy Due to Different Kinetics of IgM Clearance and IgG Avidity Index Maturation.
作者： Maurizio Zavattoni , Daniele Lilleri , Fausto Baldanti , Antonella Sarasini , Chiara Fornara
DOI: 10.3390/DIAGNOSTICS11030396
关键词: Human cytomegalovirus 、 Medicine 、 Avidity 、 Seroconversion 、 Antibody 、 Population 、 Serology 、 Pregnancy 、 Igg avidity 、 Immunology
摘要: Primary infection occurs when seronegative women are infected by human cytomegalovirus (HCMV). Diagnosis of primary is based on the following: antibody seroconversion, presence IgM and low IgG avidity index (AI), DNAemia. The kinetics HCMV-specific maturation AI might be very rapid or long-lasting during infection, which makes serological diagnosis insidious. aims this study were as follows: (i) to report atypical early after onset HCMV in a population pregnant women, (ii) assess frequency such results. Altogether, 1309 sequential serum samples collected from 465 with included study. As general rule, using LIAISON®CMVIgMII LIAISON®CMVIgGAvidityII assays, virus-specific levels decreased, while increased over time first three months onset. However, clearance and/or occurred 46/426 (10.7%) women. In more details, 20/426 (4.7%) 26/418 (6.2%) had undetectable high AI, respectively, tested within 1–3 well-defined Twenty sera many LIAISON assay further for VIDAS®CMVIgGAvidityII Mikrogen recomLineCMVIgG Avidity assays. Comparable results obtained VIDAS, whereas 14/20 gave assay. conclusion, about 11% undergoing showed misleading Additional appropriate testing help reducing risk missing pregnancy. Furthermore, preconceptional should strongly recommended.
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