Tear cytokines in acute and chronic ocular allergic inflammation.

摘要: Purpose of review Elevated levels inflammatory cytokines have been reported in tears from ocular allergic disease states. The purpose this is to assimilate recent research contrasting tear cytokine concentrations non-allergic subjects versus with acute (seasonal conjunctivitis) and chronic (giant papillary conjunctivitis, vernal keratoconjunctivitis, atopic keratoconjunctivitis) inflammation discover whether the profiles could provide useful insight into mechanisms therapeutic targets. Recent findings studies revealed distinct differences cytokine/chemokine between various manifestations allergy. iatrogenic forms are characterized by an overall lack significant changes compared (vernal keratoconjunctivitis). Chronic produces increased T helper 1 2, proinflammatory as well chemokines. However, keratoconjunctivitis portray patterns cytokines/chemokines expressed. Summary plethora chemokines non-allergic, seasonal conjunctivitis giant provides a new perspective complex processes occurring on surface disease. ability measure multiple tears, combined knowledge obtained in-vitro analysis individual effects these conjunctival cells (i.e. mast cells, epithelial fibroblasts) has facilitated further understanding specific contributing maintenance progression vision-threatening paved way toward