Treatment of staphylococcal ventriculitis associated with external cerebrospinal fluid drains: a prospective randomized trial of intravenous compared with intraventricular vancomycin therapy.

摘要: Object. Staphylococcal ventriculitis may be a complication in temporary external ventricular drains (EVDs). The limited penetration of vancomycin into the cerebrospinal fluid (CSF) is well known; pharmacodynamics and efficacy systemically compared with intraventricularly administered examined this prospective study. Methods. Ten patients whom EVDs were implanted to treat intracranial hemorrhage who suffering from drain-associated randomized two treatment groups. Five these (median age 47 years) treated 2 g/day intravenously (four infusions/day, Group 1), other five 49 received 10 mg once daily (Group 2). Vancomycin levels measured serum CSF six times day. maximum level was 1.73 ± 0.4 µg/ml 1 565.58 168.71 hour after application (mean standard deviation). Vancomyci...