Atrial natriuretic factor inhibits adrenergic and purinergic neurotransmission in the rabbit isolated vas deferens.

摘要: This study tests the hypothesis that atrial natriuretic factor (ANF) acts to inhibit neurotransmission in rabbit vas deferens. The deferens is a unique model of autonomic it composed primarily nonvascular smooth muscle and has both purinergic or twitch contraction an adrenergic phasic associated with its response electrical stimulation. In this ANF was found inhibited electrically induced norepinephrine release concentration-dependent manner over concentration range 10(-10) 10(-7) M. at M had no effect on norepinephrine-induced ATP-induced contractions. Therefore, neuromodulatory appears be prejunctional, neurotransmitters ATP from nerve terminal not postjunctional muscle. Neither alpha-2 antagonist rauwolscine nor cyclooxygenase inhibitor indomethacin any inhibitory Additionally, did affect vasa deferentia prostaglandin E production. mediated via receptors observed effects may involved hypotensive including natriuresis, diuresis vasodilation.