Sugars Specifically Labeled with Isotopes of Hydrogen

摘要: Publisher Summary This chapter discusses sugars in which a hydrogen isotope forms carbon-hydrogen bond. The use of the two isotopes—deuterium and tritium—differs considerably as former is stable isotope, generally used at 100% substitution, whereas latter minute proportions tracer. It noted that methods preparing specifically labeled with either deuterium or tritium are similar. As tritiated substitution not used, therefore possibility dilution unlabeled material makes their synthesis, and, particularly, isolation, easier. In most preparative methods, an effect can be observed, leading to specific activity product lower than expected. does apply essentially equilibrium-exchange when isotopically pure reagent introduce atom. achievable compounds limited by radioactivity, causes chemical decomposition.