Clonal evolution as detected by interphase fluorescence in situ hybridization is associated with worse overall survival in a population-based analysis of patients with chronic lymphocytic leukemia in British Columbia, Canada.

摘要: This study evaluates prognostic markers as predictors of clonal evolution (CE) and assesses the impact CE on overall survival (OS) in a population-based cohort 159 consecutive eligible patients with chronic lymphocytic leukemia (CLL) obtained from British Columbia Provincial CLL Database. was detected by interphase fluorescence situ hybridization (FISH) 34/159 (21%) 65% acquiring deletion 17p or 11q. CD38 positive status (≥30%) flow cytometry predicted 2.7 times increased risk high-risk (acquisition 11q) multivariate analysis. Prior therapy not significant predictor CE. associated 4.1 greater death when analyzed time-dependent variable for OS after adjusting age, lymphocyte count, FISH timing. High-risk worse while acquisition low/intermediate-risk abnormalities (trisomy 12, 13q, IGH translocation) had no difference OS. Our demonstrates negative this cohort. These data provide support repeating testing during follow-up have reduced may require closer observation.