Corticosteroids as treatment of epileptic syndromes with continuous spike‐waves during slow‐wave sleep

摘要: To assess the efficacy and tolerability of steroids in epileptic syndromes with continuous spike-waves during slow-wave sleep (CSWS), charts 44 children (25 boys) who received corticosteroids for cognitive and/or behavioral deterioration associated CSWS were retrospectively reviewed. Awake electroencephalography (EEG) records, clinical neuropsychological assessments available before, during, after corticosteroid therapy. Evaluation focused on effects EEG, behavior, cognition. All but two patients hydrocortisone (initial dose 5 mg/kg/day). The treatment was slowly tapered a total duration 21 months. There 18 symptomatic 26 cryptogenic cases. Mean age 7 years mean intelligence quotient/developmental quotient (IQ/DQ) 65. before 1.7 years. Twenty had tried more than antiepileptic drugs (AEDs) steroids. Positive response to found first 3 months 34 (77.2%), normalization EEG patients. Relapse occurred 14 them. Hence, 20 (45.4%) long-term responders single prolonged trial steroids, including all four cases Landau-Kleffner syndrome. highly significantly higher IQ/DQ. Shorter duration, not age, etiology, or previous AED trials, positive Early discontinuation side encountered seven We conclude that are safe efficient epilepsy CSWS. Poor very low IQ long