Effects of high-dose intravenous corticosteroid therapy in Landau-Kleffner syndrome
作者： Tomohiko Tsuru , Masato Mori , Masashi Mizuguchi , Mariko Y Momoi
DOI: 10.1016/S0887-8994(99)00127-7
关键词:
摘要: Two children with Landau-Kleffner syndrome were successfully treated antiepileptic drugs and a high-dose intravenous corticosteroid. A combination of valproate benzodiazepine (clonazepam or diazepam) ameliorated epileptic seizures electroencephalographic spikes waves, but speech disturbances persisted. Both patients an infusion methylprednisolone sodium succinate (20 mg/kg daily) for 3 consecutive days. This was repeated three times 4-day interval between treatments, which resulted in rapid improvement ability. After therapy, prednisolone given orally (2 daily 1 month, then gradually withdrawn), maintained the clinical speech.
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