Mechanisms and regulation of cholesterol homeostasis

作者: Jie Luo , Hongyuan Yang , Bao-Liang Song , None

DOI: 10.1038/S41580-019-0190-7

关键词: SecretionCholesterolLipid dropletBiosynthesisCell biologyFunction (biology)ChemistrySterolCell signalingCell

摘要: … Disturbed cholesterol balance underlies not only cardiovascular disease but also an … diseases and cancers. The cellular cholesterol level reflects the dynamic balance between …

参考文章(348)
D N Croft, Body iron loss and cell loss from epithelia. Journal of the Royal Society of Medicine. ,vol. 63, pp. 1221- 1224 ,(1970) , 10.1177/003591577006301204
Daqian Xu, Zheng Wang, Yuxue Zhang, Wei Jiang, Yi Pan, Bao-Liang Song, Yan Chen, PAQR3 modulates cholesterol homeostasis by anchoring Scap/SREBP complex to the Golgi apparatus Nature Communications. ,vol. 6, pp. 8100- 8100 ,(2015) , 10.1038/NCOMMS9100
Kimberly K. Buhman, Michel Accad, Sabine Novak, Rebekah S. Choi, Jinny S. Wong, Robert L. Hamilton, Stephen Turley, Robert V. Farese, Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient mice. Nature Medicine. ,vol. 6, pp. 1341- 1347 ,(2000) , 10.1038/82153
Ca Feltkamp, Apm Jongsma, J Elema, L Deley, M Brouwer, Serum-dependent “Cannibalism” and Autodestruction in Cultures of Human Small Cell Carcinoma of the Lung Cancer Research. ,vol. 44, pp. 2947- 2951 ,(1984)
Christopher P Cannon, Michael A Blazing, Robert P Giugliano, Amy McCagg, Jennifer A White, Pierre Theroux, Harald Darius, Basil S Lewis, Ton Oude Ophuis, J Wouter Jukema, Gaetano M De Ferrari, Witold Ruzyllo, Paul De Lucca, KyungAh Im, Erin A Bohula, Craig Reist, Stephen D Wiviott, Andrew M Tershakovec, Thomas A Musliner, Eugene Braunwald, Robert M Califf, None, Ezetimibe added to statin therapy after acute coronary syndromes The New England Journal of Medicine. ,vol. 372, pp. 2387- 2397 ,(2015) , 10.1056/NEJMOA1410489
R. Ren, X. Zhou, Y. He, M. Ke, J. Wu, X. Liu, C. Yan, Y. Wu, X. Gong, X. Lei, S. F. Yan, A. Radhakrishnan, N. Yan, Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels Science. ,vol. 349, pp. 187- 191 ,(2015) , 10.1126/SCIENCE.AAB1091
L Liscum, J Finer-Moore, R M Stroud, K L Luskey, M S Brown, J L Goldstein, Domain structure of 3-hydroxy-3-methylglutaryl coenzyme A reductase, a glycoprotein of the endoplasmic reticulum. Journal of Biological Chemistry. ,vol. 260, pp. 522- 530 ,(1985) , 10.1016/S0021-9258(18)89764-2
Bei-Bei Chu, Liang Ge, Chang Xie, Yang Zhao, Hong-Hua Miao, Jing Wang, Bo-Liang Li, Bao-Liang Song, Requirement of myosin Vb.Rab11a.Rab11-FIP2 complex in cholesterol-regulated translocation of NPC1L1 to the cell surface. Journal of Biological Chemistry. ,vol. 284, pp. 22481- 22490 ,(2009) , 10.1074/JBC.M109.034355