Studies on the synthesis of sesquiterpene lactones, 12. Synthesis of (+)-colartin, (+)-arbusculin A, and their C-4 epimers and their biological activities.

作者： Masayoshi Ando , Koji Isogai , Hidenori Azami , Naonori Hirata , Yoshikazu Yanagi

关键词: Leukemia 、 In vitro 、 Organic chemistry 、 Epimer 、 Plant growth 、 Cell growth 、 Sesquiterpene 、 Stereochemistry 、 Chemistry

摘要: Colartin [9] and arbusculin A [11] have been synthesized from alpha-santonin [1] in 14.5% (11 steps) 9.3% (13 overall yields, respectively. Arbusculin compounds 20, 21, 22, which were derived intermediate 2, showed significant cell growth inhibitory activity against murine lymphocytic leukemia (P-388) vitro. Plant regulating of 11 its synthetic intermediates 4, 5, 8, 9 was also studied.