Taurine attenuates the damage of lupus nephritis mouse via inactivation of the NF-κB pathway.

摘要: Background Taurine is an organic amino acid and a major constituent of bile. With its contribution to various cellular functions, it has demonstrated therapeutic effects in wide range diseases. Since there lack literature investigating taurine as treatment for lupus nephritis (LN), here we examined the potential LN. Methods Experiments were carried out using MRL/lpr mice model LN, C57BL/6 used negative controls. At 12 weeks old, divided into four groups treated with 0, 50 100 mg/kg body weight 5 days. Enalapril positive control drug. All animals sacrificed after treatment. LN-induced damage was assessed by proteinuria, blood urea nitrogen (BUN) serum creatinine (CRE) levels. The degree inflammation inducible nitric oxide synthase (iNOS), interleukin-4 (IL-4), IL-10, tumor necrosis factor-α (TNF-α) oxidative stress malondialdehyde (MDA), reactive oxygen species (ROS), superoxide dismutase (SOD), glutathione peroxidase (Gpx) Hematoxylin eosin (HE) staining TUNEL histopathological apoptosis, respectively. levels Bcl-2, Bax, caspase-3, caspase-9, NF-κB p65 detected western blot. Results data indicated that administration improved kidney reversed cell death, suppressed stress, importantly, adjusted immune response LN more balanced state. Conclusions These results provide novel strategy therapy, which may overcome disadvantages traditional immunosuppression hormone treatments greater efficacy fewer side effects.