Spectral Features Control Temporal Plasticity in Auditory Cortex

摘要: Cortical responses are adjusted and optimized throughout life to meet changing behavioral demands compensate for peripheral damage. The cholinergic nucleus basalis (NB) gates cortical plasticity focuses learning on behaviorally meaningful stimuli. By systematically varying the acoustic parameters of sound paired with NB activation, we have previously shown that tone frequency amplitude modulation rate alter topography selectivity tuning in primary auditory cortex. This result suggests network-level rules operate cortex guide reorganization based specific features sensory input associated activity. report summarizes recent evidence temporal response properties neurons influenced by spectral characteristics sounds modulation. For example, repeated pairing a spectrally complex (ripple) stimulus decreased minimum latency ripple, but lengthened tones. Pairing rapid train tones activation only increased maximum following when carrier each was randomly varied. These results suggest experiences interact shape spectrotemporal Additional experiments more stimuli needed clarify how learns natural such as speech.