Cortical network reorganization guided by sensory input features.

摘要: Sensory experience alters the functional organization of cortical networks. Previous studies using behavioral training motivated by aversive or rewarding stimuli have demonstrated that plasticity is specific to salient inputs in sensory environment. associated with electrical activation basal forebrain (BasF) generates similar input plasticity. By directly engaging mechanisms and avoiding extensive training, BasF stimulation makes it possible efficiently explore how features contribute This review summarizes our observations networks employ a variety strategies improve representation Different combinations receptive-field, temporal, spectrotemporal were generated primary auditory cortex neurons depending on pitch, modulation rate, order sounds paired stimulation. Simple tones led map expansion, while modulated altered maximum following rate. Exposure complex acoustic sequences development combination-sensitive responses. remodeling response characteristics may reflect changes intrinsic cellular mechanisms, synaptic efficacy, local neuronal connectivity. The intricate relationship between pattern suggests network-level rules alter generate most behaviorally useful