Clinical significance of side population in ovarian cancer cells

摘要: Recently, accumulating evidence has suggested that tumors, including ovarian cancer, are composed of a heterogeneous cell population with small subset cancer stem cells (CSCs) sustain tumor formation and growth. The emergence drug resistance is one the most difficult problems in treatment which been explained recently by potential CSCs to have superior against anti-cancer drugs than conventional cells. In this study, we expanded line study examine whether phenomenon also observed clinical specimens total could analyze 28 samples out 60 obtained from patients. were subjected testing expression side (SP) as CSC marker, according presence SP (SP+) or absence (SP−), clinicopathological significances analyzed. Although there was no statistical significance, more SP+s recurrent cases well ascitic peritoneal dissemination primary ovary. There correlation between status FIGO staging. 19 those who be followed 6 months initial therapy, 8 recurrence death disease, all these SP+. On other hand, 11 disease-free survivors, 6 significant difference prognosis SP+ SP− (p = 0.017). limited, it revealed contained metastatic tumors risk factor cancer. Therefore, novel therapeutic strategy targeting improve